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Chunk #9 — Method — Measures

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Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.
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We evaluated 17 psychophysiological measures, all of which, except affectively modulated startle, have received support as endophenotypes for schizophrenia. All measures have been described in detail previously (Iacono et al. 2014a; Vrieze et al. 2014b). All measures were corrected for sex, age, parent/child and technical artifacts. Measures were inverse-normalized prior to genetic association to mitigate outlier effects.