Chunk #75 — Figure 1

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Power and predictive accuracy of polygenic risk scores.

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Expected −log10(P) of linear regression estimate as a function of P-value threshold for selecting markers into the polygenic score.Training sample, 3322 cases and 3587 controls; replication sample, 2687 cases and 2656 controls. Marker panel of 74062 independent SNPs. Variance explained by markers, 28.7%. pi0, proportion of markers with no effect on disease.