Given the known association between low P3 amplitude and theta ERO values with risk for alcoholism (Euser et al., 2012; Rangaswamy and Porjesz, 2008; Jones et al., 2006a; Porjesz et al., 2005), we attempted to control the effect of selecting 80% of the subjects from families initially recruited through an alcoholic family by including a family type indicator (alcoholic or community family) in the regression model. The effect of family type was not found to be significant in the statistical analysis. Additionally, no significant association at the GWAS level between alcohol use disorder phenotypes and any of the KCNJ6 SNPs used in the study in adults was found using the same sample and methodology as that used in Kang et al. (2012). We know of no other study which shows association between these KCNJ6 SNPs and alcoholism case-control status.
