The results of testing the best PGS in the AOU and IB cohorts are presented in Table 2. All high-risk or low-risk groups were associated with AUD when compared with the remaining samples. The top 5% of samples had the highest risk in both the AOU (OR, 1.96 [95% CI, 1.78-2.16]) and IB (OR, 2.07 [95% CI, 1.59-2.71]) cohorts, and they were 2 times more likely to develop AUD. The risk of AUD development was approximately half for samples in the bottom percentages of risk in the AOU and IB cohorts: The bottom 10% had the lowest risk in the AOU cohort (OR, 0.52 [95% CI, 0.46-0.58]), whereas the bottom 5% had the lowest risk in the IB cohort (OR, 0.57 [95% CI, 0.39-0.84]). However, the bottom 5% in the AOU cohort had the second lowest risk (OR, 0.53 [95% CI, 0.45-0.62]); therefore, we used the bottom 5% in sex-stratified analysis with results presented in Table 3. All PGSs were associated with AUD except the bottom 5% in females in the IB cohort. Overall, males and females had similar results.
