genetically uncorrelated and biologically diverse traits, representative of the summary statistics analyzed. These five traits include an allergic phenotype (asthma), an autoimmune disease (rheumatoid arthritis (RA)), a neoplastic type (prostate cancer (PrCa)), a hematological quantitative trait (mean corpuscular volume (MCV)) and an anthropometric trait (height). We highlight the four leading IMPACT annotations associated with EUR summary statistics for each of the five exemplary phenotypes (Fig. 2b; associations between all traits and annotations in Extended Data Fig. 2). Consistent with known biology, B and T cells were strongly associated with asthma42, RA43 and MCV44,45, while other blood cell annotations derived predominantly from GATA factors were also associated with MCV. Prostate cancer cell lines were associated with PrCa, while diverse cell types including myoblasts46, fibroblasts47, adipocytes48,49, lung cells and endothelial cells were associated with height, perhaps related to musculo-skeletal developmental pathways.
