Chunk #7 — MATERIALS AND METHODS — Statistical analysis

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Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.

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Coding variants that passed quality control were divided into three classes based on the derived MAF in the entire sample: rare (MAF<0.005), low frequency (0.05>MAF≥0.005), and common (MAF≥0.05). Visual examination of the distribution of the allele frequencies in the sample (Supplementary Figure S1) highlights a natural grouping of these three frequency classes.