Yet others may be involved in alcohol-related pathology, for example, the interaction of alcohol and lipid metabolism is fundamental to the pathogenesis of alcoholic fatty liver, hyperlipidemia and atherosclerosis produced by excessive alcohol consumption (Feinman and Lieber 1999). Our study has highlighted genes encoding transcription factors, regulatory proteins, lipid metabolism, cell signaling, and it is plausible that variants of these genes may be involved in risk for AD as well as alcohol-related pathology such as liver dysfunction.
