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Chunk #18 — Materials And Methods — Linkage disequilibrium

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A genome-wide association study of autism reveals a common novel risk locus at 5p14.1.
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Linkage disequilibrium (LD) patterns and haplotype block delineation were determined by using Haploview 4.1 (Choi et al. 2001). Blocks were defined using the confidence interval method described by Gabriel et al. (Gabriel et al. 2002). Pair-wise LD measures (r2) were calculated in the 3,822 unrelated founders of the join sample