A genome-wide scan in a Greenlandic Inuit population, for example, found last year that a single-nucleotide polymorphism (SNP) in a fatty-acid enzyme affects height in both this population and Europeans7. The authors suggest that previous GWAS may have missed this variant because of its low frequency in Europeans (0.017 compared to 0.98 in the Greenlandic Inuit population) — even though it has a much greater effect on height than others previously identified through GWAS.
