al., 1987) and anti-nociceptive effects (Kovacs et al., 1985) in mice. With regards to psychostimulants, higher doses of OXT have been shown to reduce locomotor hyperactivity and stereotyped behaviors induced by cocaine (Kovacs et al., 1990, Sarnyai et al., 1991, Sarnyai et al., 1992) and methamphetamine (Carson et al., 2010a, Qi et al., 2008), but not amphetamine (Sarnyai and Kovacs, 1994, Kovacs et al., 1985). Interestingly, lower doses of OXT were unable to prevent the development of tolerance or sensitization in rodents (Sarnyai et al., 1992). Repeated systemic administration (ip.) of OXT prevented the development of tolerance to the hypothermic, hypnotic and ataxic effects of alcohol (Jodogne et al., 1991, Szabo et al., 1985, Szabo et al., 1989). However, once tolerance had developed, OXT treatment had no effect on tolerance to the effects of alcohol (Szabo et al., 1985).
