To examine phenotypes that were genetically correlated with the addiction-rf, we calculated genetic correlations using LD score regression54,71 through the MASSIVE pipeline72, which conducts LD score regression13,46 and Latent Causal Variable Analysis28 on 1,547 summary statistics for various phenotypic traits, including a mixture of ICD codes and self-reported traits from the UK Biobank and publicly available meta-analyses from GWAS consortiums.
