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Chunk #28 — Materials and Methods — Study descriptions — Nicotine gum study (Study 1)

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Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers.
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This study was a randomized double-blind, placebo-controlled trial to evaluate the efficacy of nicotine gum (2 mg) in African American light smokers (6). Eligible participants self-identified as “African American” or “Black”, were at least 18 years old, had smoked 10 or fewer CPD for at least 6 months prior to enrollment, and smoked on at least 25 of last 30 days. This study consisted of four treatment arms (N=∼190 each): 1) nicotine gum with health education (HE) counseling; 2) nicotine gum with motivational interviewing (MI) counseling; 3) placebo with HE and 4) placebo with MI. The nicotine gum treatment lasted 8 weeks, and six counseling sessions were provided to each participant. The participants were followed for a total of 26 weeks (6 months).