Chunk #15 — Materials and Methods — Genotyping and Data Analysis — Local imputation of functional locus Arg272Gln (rs1693482)

Source

Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.

Embedded

yes

Text

The SNP rs1693482 was imputed locally using BEAGLE 3.3 (Browning & Browning 2007) and default settings. Genotype data from the 60 Hapmap (The International HapMap Consortium 2005) CEU founders (release 23a) were used as a reference panel in order to allow comparison of our results with previously reported findings for SNP rs1693482, which was not present in the overlap of the applied genotyping platforms.