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Chunk #11 — Methods — Samples

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A Developmentally-Informative Genome-wide Association Study of Alcohol Use Frequency.
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ALSPAC is a large longitudinal birth cohort which includes reports from approximately 14,000 children and their parents from early in the mothers’ pregnancy through childhood, adolescence, and emerging adulthood (Boyd et al. 2013; Fraser et al. 2013; Northstone et al. 2019). Pregnant women residing in Avon, UK with expected dates of delivery between 1st April 1991 and 31st December 1992 were invited to take part in the study. The total sample size for analyses using any data collected after the age of seven is therefore 15,447 pregnancies, resulting in 15,658 fetuses. Of these, 14,901 children were alive at 1 year of age. The project has collected comprehensive health-related information, including phenotypic outcomes, environmental factors, and DNA, with >85 assessments from mothers, their partners, and children, conducted from the prenatal stage through emerging adulthood at yearly, or more frequent, intervals. Please note that the study website contains details of all the data that is available through a fully searchable data dictionary and variable search tool (http://www.bristol.ac.uk/alspac/researchers/our-data/). Study data were collected and managed using REDCap electronic data capture tools hosted at the