We utilized publicly available data generated by the ENCODE Project [41] to identify SNPs overlapping regulatory DNA as denoted by the presence of a DNase I hypersensitivity site (DHS) or H3K4me4 histone modification (see Supplemental Material). We examined whether SNPs with lower p-values were more likely to localize within these regulatory regions by performing an enrichment analysis using an increasingly selective inclusion criterion based on association p-value.
