In this way, our study extends beyond preceding studies that led us to examine trafficking of GluR1-containing AMPARs. Our analysis shows that trafficking of GluR1-containing AMPARs is evoked not only after LTP induction within hippocampal slices or following sensory experience during development (Takahashi et al., 2003) but also within intact LA following fear learning in adulthood. Moreover, we show that this can be achieved through the rapid trafficking of endogenous GluR1-AMPARs, without depleting the nonsynaptic reserve pool of GluR1-AMPAR, leading to behavior, emotion, and arousal that are robustly plastic, yet also specific and protected from the overgeneralizations associated with anxiety disorders.
