The present report is part of a larger study exploring risk factors for substance dependence among Native American Indians (see Ehlers et al., 2001a,b,c,d; 2004a, 2008c; Gilder et al., 2004, 2006, 2007, 2009). The lifetime prevalence of substance dependence in this Indian population is high and evidence for heritability and linkage to specific chromosome locations and associations with candidate genes has been demonstrated (see Wall et al., 2003; Ehlers et al., 2004b, 2006b, 2007a,b,c, 2008a,b, 2009a,b, 2010a; Ehlers and Wilhelmsen, 2005, 2007; Wilhelmsen and Ehlers, 2005). The current study’s aims were to: (1) map loci linked to SRE phenotypes and (2) to determine if there was overlap of the loci identified for SRE phenotypes and loci previously mapped for alcohol and other substance dependence in this American Indian community.
