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Chunk #26 — Results

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Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
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Next, these 11 RVs were analyzed together by the SKAT method. The power to detect RVs with relative risk of 2 for AD, CD and OD increased to 76%, 70% and 80% in AAs; 75%, 80% and 85% in EAs (Figure S3A and S3B). This indicates that the test had adequate power. A statistically significant association was observed in AAs for OD, with P=0.00080 (Table 3). This was highly significance based on Bonferroni correction for multiple testing (P=0.0083).