rs13147758 (P = 5.30 × 10−10 for FEV1 and P = 1.11 × 10−12 1 for FEV1/FVC in our data), and with SNPs associated previously with height (rs6854783, r2 = 0.55; rs2055059, r2 = 0.48), suggesting a role in skeletal growth and development. The hedgehog gene family, of which HHIP is a member, encodes signaling molecules involved in regulating lung morphogenesis, suggesting other mechanisms underlying these associations13. This intergenic region also contains multiple ESTs in human fetal lung (UCSC Browser).
