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Chunk #1 — Introduction

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Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions.
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A common analysis strategy for such studies is to separately analyze each condition in turn, then compare the “significant” results among conditions. Although appealingly simple, this “condition-by-condition” approach is unsatisfactory in several ways: it under-represents sharing of effects among conditions because shared effects will be insignificant in some conditions by chance, and it misses the power gains that come from sharing information across conditions5.