In EAs and AAs, 768,146 and 870,103 SNPs, respectively, passed quality control steps. Based on Bonferroni correction for multiple comparisons, the threshold of genome-wide significance was 6.51 ×10−8 for EAs and 5.75×10−8 for AAs. The genomic inflation factor λs were 1.010 and 1.003 for EAs and AAs, respectively. The quartile-quartile plots are shown in Figures 1A and B. In EAs (Table 2), one SNP, rs406001 on chromosome 7p12, exceeded the genome-wide significant threshold for association with p = 3.97×10−8 (Figure 2A). Another two SNPs in the same region, rs382903 and rs450378, were the second and fourth most significant SNPs. The three SNPs are located approximately 630 kilobase downstream of the nearest gene Cordon-Bleu (COBL). The region showing the second strongest evidence of association was chromosome 4q32 (Figure 2B), which is in the first intron of Tolloid-Like 1 gene (TLL1). The top SNP rs6812849 reached a p value of 2.99×10−7. Another two SNPs in the same region, rs7691872 and rs1503292, were the sixth and seventh most significant SNPs. The SNPs ranked as the eighth and ninth most significant were located in
