The results of our meta-analysis, as well as those of de Moor et al.,15 demonstrate that the null GWAS findings are not simply due to the instrument used, and appear to suggest that successful mapping of loci contributing to personality will require new strategies and methodology. Additionally, next-generation sequencing soon will provide a host of data that may reveal rare variants that, when aggregated in the form of a ‘burden analysis',43 account for variability in personality traits. Understanding the biological processes underlying personality-related traits would be greatly facilitated by discovery of any such associated loci, and such loci may also provide a window for understanding cognitive and behavioral disorders.
