Chunk #6 — Materials and Methods — Genotypes

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Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways.

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We implemented a unifying strategy that employed both genotyped and imputed SNPs to analyze the same set of SNPs in each of the three studies (Text S2). We analyzed all of the SNPs included in the Illumina Human 1 M beadchip to maximize the signals ascertained in the two exploratory studies.