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Chunk #14 — Fronto-limbic circuit — Treatments targeting fronto-limbic dysfunctions in OCD

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Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder.
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with findings from a recent systematic review and meta-analysis [62] of 18 randomized controlled trials (RCTs) evaluating the efficacy of rTMS for OCD, which showed that low-frequency and high-frequency rTMS were both superior to sham in improving OCD symptoms. Finally, a recently published, large (n=99) multicenter randomized clinical trial showed that deep TMS targeting mPFC and the anterior cingulate cortex, associated with individualized symptom provocation, was superior to sham in improving OCD symptoms [63].