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Chunk #36 — Methods — pPS Predictivity in uniform genomes

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Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals.
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As a local ancestry pattern is essentially a subset of the genome obtained superimposing a mask onto the genomic fragments of other ancestries, we could apply the same subsetting mechanism to other genomes, even if non-admixed. We chose randomly 200 European local ancestry/subsets from our admixed sets. Each of the drawn subsets (masks) obtained in the local ancestry analysis was applied to the whole EstBB dataset to obtain a pPS distribution and predicted R2 was used as measure of predictivity. For binary traits we adopted a logistic model and the Nagelkerke R2.