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Chunk #33 — RESULTS — Predicting a patient’s responsiveness to Li according to electrophysiological measurements

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Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium.
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patient each time. Since a patch-clamp recording session usually consists of patching a few neurons, to improve performance, we used, as the test data, 1-, 3- or 5-cell recordings (from 1 or 3 or 5 cells accordingly, see Materials and Methods). The recordings were chosen randomly from the recordings of the patient being classified, and this procedure was repeated randomly 2000 times to get a statistical estimate of the success rate. When classifying patient SBP001 (NR) according to one patch clamped neuron, the success rate was 76%; classifying according to 3-cell recordings gave a success rate of 83%, and with 5-cell recordings, the success rate was 92%. When classifying patient SBP002 (NR) with a 1-neuron recording, the success rate was 88%; with 3-cell recordings, the success rate was 100%, and with 5-cell recordings it was 100% as well. When classifying patient SBP004 (NR) with 1-neuron recordings, the success rate was 62%; with 3-cell recordings, the success rate was 81%, and with 5-cell recordings it was 88%. When classifying patient SBP005 (LR) with 1-neuron recordings, the success rate was 67%; with 3-cell recordings, the success rate was 81%, and with 5-cell recordings it was 90%. When classifying patient SBP007 (LR) with