Additional studies with a larger number of participants in each Caine subgroup may unveil relationships among neurological, nutritional, and cognitive factors that were not observed in this study for lack of statistical power when examining subgroups. In addition, a historical signature or biomarker of thiamine deficiency over the lifespan would enable further investigation of the relation between thiamine and susceptibility of impairment of diencephalic, medial temporal, and cerebellar structures and associated cognitive and motor deficits.
