in those who also reported rVUS as well as in early-onset compared with never/late-onset cannabis users (Table S6); however, we are unaware of the extent to which they contributed to rVUS. Finally, reporting bias in age at initiation of cannabis use may have influenced assignment of twins to discordant pairs and our overall findings – this bias is likely to be modest as the average difference in age between early and late-onset twins was 3.6 years (2.2 years within discordant MZ pairs). We also show several additional analyses that demonstrate consistency of findings across age cutoffs (Table S2-S4). However, the cross-sectional nature of our data may have impacted these results in other, unobserved ways.
