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Chunk #40 — DISCUSSION — Effects of a passive three-tone auditory ‘oddball’ paradigm on ERO energy and PLI — B6 and D2 mice

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Event-related oscillations as risk markers in genetic mouse models of high alcohol preference.
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While ERPs have been successfully recorded in a number of animal species the use of ERO technology to study brain function in animal models has been less applied (Schurmann et al., 2000). The present studies extend and confirm findings demonstrating that EROs can be recorded in mice. EROs have been previously reported in the delta, theta and alpha/beta ranges in response to auditory stimuli that were impacted by differences in stimulus characteristics (Ehlers and Criado, in press). In that study oscillations in the 7.5–40 Hz frequencies were found to be significantly affected in the 0–50 msec time range in response to differences in tone frequency. Whereas, changes in tone loudness produced changes in oscillations in the 7.5–40 Hz frequencies in the 350–800 msec range. In a separate study, evoked gamma oscillations were reported in mice that were enhanced by nicotine and blocked by pretreatment with mecamylamine (Phillips et al., 2007).