GENEVA (Gene Environment Association Studies) is a multi-site collaborative program initiated in 2006 as part of the National Institutes of Health (NIH) Genes, Environment and Health Initiative (GEI) that aims to accelerate the understanding of genetic and environmental contributions to health and disease [Cornelis et al., 2010]. The GENEVA consortium, led by the National Human Genome Research Institute (NHGRI) and working closely with representatives from several institutes at the NIH, includes a Coordinating Center (CC), two genotyping centers, and fourteen independently-designed GWAS whose primary outcomes of interest include addiction, blood pressure, cardiovascular disease, chronic obstructive pulmonary disease, dental caries, type 2 diabetes, lung cancer, maternal metabolism and birth weight interactions, oral clefts, premature birth, primary open-angle glaucoma, prostate cancer, stroke, and venous thrombosis. Two additional GWAS examining coagulation and melanoma joined the consortium in 2009. Each study has collected relevant environmental exposure data. The participating studies vary widely in design: some of the longitudinal studies have been ongoing for years or even decades, others have international data collection sites, and some are family-based studies with phenotype and genotype data available
