We conducted a genome-wide association meta-analysis of depression using 807,553 individuals (Table 1; 246,363 cases and 561,190 controls) from three previous studies of depression, after removing sample overlap; the previous studies were Hyde, et al. 8 Howard, et al. 5, and Wray, et al. 9. We tested the effects of 8,098,588 genetic variants on depression and identified 9,744 associated variants (P < 5 × 10-8) of which 102 variants in 101 loci were independently segregating (Supplementary Table 1). The basepair positions of these loci were identified by clumping all associated variants (linkage disequilibrium r2 < 0.1 across a 3 Mb window) and then merging any overlapping clumps. Independent variants in each locus were identified through conditional analysis using all variants in that locus.
