Phenotype labels of full exomes were permuted 1,000,000 times, i.e., permuted phenotype affected all genes in an individual. In each permutation, the lowest exome-wide p-value was computed. It took fewer than 1000 computing hours to run 8 statistical tests on the 1 million whole-exome permutations of 15,122 genes in 438 individuals. The computation is very easy to parallelize and thus quite affordable using cluster or cloud computing.
