Figure 3 shows how the power of MAGENTA increases proportionately with the fraction (Figure 3A) or number (Figure 3B) of causal genes in three different gene set sizes, for a set of parameters chosen to be consistent with the lower bound effect size found to date in T2D and glycemic traits studied herein. For a given number of causal genes, small gene sets are more powerful; for a given fraction of causal genes, big gene sets have more power. Furthermore, as may be expected, power increases with the associated SNP effect size, and decreases with the total number of causal genes in the genome (Figure S6).
