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Chunk #26 — RESULTS — Informativeness of cell-specific eQTL analysis for fine mapping and functional characterisation of GWAS

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Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.
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traits (17.3% of reported GWAS SNPs) are associated with one or more significant cis-eQTL based on the listed GWAS markers or identified proxy SNPs from the 1000 Genomes Project (CEU cohort, r2 > 0.8). A complete integrated dataset indexed by trait is provided (Supplementary Table 6). Overall, we find that 730 genes show significant cis-eQTL related to GWAS, of which 33.5% are B-cell-specific, 45.5% are monocyte-specific and 21% are found in both cell types.