Chunk #9 — Methods and Materials — Statistical Analysis — Multivariable and Gene-Environment Interaction analyses

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Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.

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To evaluate the impact of GxE interactions the predicted probabilities of nicotine dependence for number of H.S. peers who smoked were plotted and the variance in nicotine dependence attributable to smoking peers estimated by genotype. Variance explained was estimated by Nagelkerke’s adjusted R2 from logistic regression models and the difference in genotype specific R2 tested by z-test [29].