Data driven approaches have validated the veracity of the polygenic risk score approach (Chen et al., 2017), but PRS results vary across studies and are reported to be dependent on factors such as the sample, stage and/or severity of the disease (Cooke Bailey and Igo, 2016). One study reported PRS to be associated with treatment resistance (Frank et al., 2015), though another study found the evidence to be inconclusive (Martin and Mowry, 2016). PRS has also been reported to be associated with frequent hospitalizations in patients, with a suggested possibility that the association likely comes from the common variants involved in deterioration during the course of the illness (Meier et al., 2016). But PRS predictions of symptoms and cognitive dimensions have not been specifically examined in patients with chronic schizophrenia.
