Chunk #52 — Discussion

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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

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Importantly, the CMap concept is not restricted to mRNA expression. Other groups are generating proteomic or high-content imaging readouts following perturbation (Litichevskiy et al., 2017); (Rohban et al., 2017) consistent with early reports of feasibility of annotating compounds based on cellular consequences (Seiler et al., 2008).