During review of this manuscript, another GWAS was published which identified significant association to SNPs on chromosome 5p14 12. While there was significant overlap between study samples, each of these scans contained a large set of unique families, so we sought to evaluate independent evidence of the top SNP (rs4307059) reported at 5p14. This SNP happens to be directly genotyped by both Affymetrix and Illumina platforms. We have a sizable number (n=796) of affected subjects with two parents genotyped (and of predominantly similar European background). However, we observed no support for association at this locus (T:U 354:335 in favor of the minor allele, a trend in the opposite direction as reported).
