in that study were not significant in the present study. Another recent study demonstrated that polygenic risk scores reflecting additive risk for several autoimmune diseases can explain a small proportion of variance in SZ case-control status, yet the genome-wide significant SNPs from the autoimmune GWASs were not over-represented among SZ’s genome-wide significant hits when permutation-based analysis was performed (Pouget et al. 2016). The apparent disagreement between different approaches for assessing shared genetic liability thus underscores the value of examining the consensus across studies and methods (Pouget et al. 2016).
