The section directly below gives an overview of Genomic SEM followed by the validation and application of the novel method introduced here, Stratified Genomic SEM. The Supplementary Note provides additional details about the curation of the psychiatric phenotypes, model fitting procedure, results excluding self-report GWAS, comparison to prior results from the second iteration of results from the PGC cross-disorder group (i.e., CDG2)12, genetic correlations with external traits, interpretation and estimation of the Q metrics (QTrait and QSNP), multivariate GWAS simulations, multivariate MR analyses, S-LDSC results, quality control procedures, and an extended account of the limitations outlined in the Discussion.
