Correlations between network metrics and symptom measures in BD subjects revealed that the BD-related alterations of network properties were associated with increased depression. BD patients with longer characteristic path length (λ) and diminished small-world characteristics (σ) in functional networks had higher depression scores (i.e., MADRS). Given that small-worldness (σ) represents the optimal balance between network segregation (γ) and integration (λ), these results thus indicate a disruption of the functional network integration with increased depressive symptomatology.
