We identified two novel GWS association signals in COL6A3 and LOC339975, and suggestive signals in a number of loci, including two genes with prior support, KLF12 and RYR3. COL6A3, RYR3 and LOC339975 are further supported by gene-based analyses (Supplementary Table S3). We detect evidence of human replication only for LOC339975 but we observe consistent evidence across multiple MOs that COL6A3, KLF12 and RYR3 orthologs modulate behavioral response to ethanol. Human post-mortem studies show that the AD-associated allele reduces LOC339975 expression in NAc.
