In conclusion, we have replicated the genotype associations with obesity for six (FTO rs1121980, SH2B1 rs7498665, MTCH2 rs4752856, MC4R rs17782313, NEGR1 rs2815752, GNPDA2 rs10938397) of nine previously associated loci. We also quantified the combined effect of these variants on obesity risk and described the extent to which the associations with obesity are attributable to increased total and regional adipose mass. Furthermore, we illustrate the degree to which these variants increase the risk of type 2 diabetes, showing that this risk is largely dependent on BMI. These extensions of the original findings provide further insight into the role common genetic variation plays in human obesity and the associated risk of metabolic disease. However, it is also evident that the effect of these variants on obesity and type 2 diabetes risk is fairly modest. Thus, it is unlikely that in its present form this information will add substantially to current risk prediction algorithms for these diseases.
