We obtained the genome-wide association study results from the discovery 23andMe subset (23andMe_307k) from the Hyde, et al. 8 analysis. Phenotypic status was based on responses to web-based surveys with individuals that self-reported as having received a clinical diagnosis or treatment for depression classified as cases. This provided a total of 75,607 cases and 231,747 controls (n = 307,354, prevalence = 0.25). We excluded variants with an imputation accuracy threshold < 0.6 and with a minor allele frequency < 0.005, which left a total of 8,995,180 variants.
