Chunk #20 — Methods and Materials — Meta-analysis

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Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.

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Finally, we attempted to replicate previous rare variant associations referenced in the introduction and listed in Table S4. We attempted replication in our phenotypes for any single variant when that variant was directly genotyped or imputed. We applied a liberal threshold that corrected only for the number of tests conducted for this replication exercise (.05/46=.001).