which is consistent with the notion that FGF21 is regulated by PPARα (Badman et al., 2007; Inagaki et al., 2007). After ethanol feeding, while serum FGF21 was increased in Pparα+/+ mice, serum FGF21 was still undetectable in Pparα−/− mice. Administration of rFGF21 completely restored serum FGF21 in Pparα−/− mice. These results suggest that ethanol induction of FGF21 is regulated by PPARα.
