The differentially expressed miRNAs clustered into 12 modules, including M grey (Fig 1B). Module sizes varied from 73 transcripts (M turquoise) to five transcripts (M greenyellow and M purple), with M grey containing four otherwise unassigned transcripts. After correlation to matching demographics and smoking status, only one module, M black, was significantly correlated with PMI (subsequently removed from analysis). Of the remaining modules, three (M blue, M yellow and M brown) were significantly correlated with AD status (adj. p≤ 0.05) (Fig 2B). These three modules contained 41% of the 240 differentially expressed miRNAs analyzed by WGCNA. A full table containing module size, correlations, and p-values for all modules is available in S2 Table.
