are also not detected in any other siblings. In the context of this large pedigree, since the probability of (i) far exceeds both (ii) and (iii), it is reasonable to treat those ‘unique’ CNVs as false positive calls. Before signal adjustment, we identified 42 unique CNV calls in the three sibships; after signal adjustment, only 15 unique CNV calls were detected, suggesting a reduction in false positive calls with wave adjustment.
