There are some differences between our results and previously published studies (Hill and Bray, 2012; Schultz et al., 2013; Williams et al., 2011), which can be explained for some of the above reasons. A recently published paper (Schultz et al., 2013) showed significant difference in general ZNF804A expression mediated by the rs1344706 SNP, and the A risk allele was associated with lower prefrontal ZNF804A expression in patients (Schultz et al., 2013), whereas the opposite effect in controls has been observed by prior analyses (Riley et al., 2010). The expression profile of ZNF804A appears to be different between patients and healthy controls in terms of an opposite effect of the risk allele. No effect of rs1344706 genotype on ZNF804A allelic expression was reported in adult brain regions (Hill and Bray, 2012; Williams et al., 2011), leading to the conclusion that the observed allelic expression imbalance was not directly attributable to rs1344706, at least in the adult brain. In fact, rs1344706 genotypes were found to have a significant effect on ZNF804A allelic expression in second-trimester fetal brain tissue, however with the SZ
