Chunk #75 — Background — Where and how the data were collected

Source

Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype.

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4. A fourth group is located in New York City. KPD is virtually unknown in New York, indicating the influence of environment on expression of the disease (people never want to share their feelings in NYC). However, the Genome Research for Elucidation of Effective Drugs Institute in NYC received a generous contract from the KPD Foundation, a non-profit group dedicated to raising awareness of KPD and as much money as they can. The GREEDI researchers chose to collect two- and three-generation pedigrees of KPD with at least four affected members.